Method for producing kakeromycin and derivatives thereof
AssigneesOp Bio Factory Co., Ltd., Seed Research Institute Co., Ltd.
InventorsTeruhiko Ishikawa, Morita Iwami
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Abstract
Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.
Claims6
A compound represented by the formula (6):
- wherein
- R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group,
- R4 is an optionally substituted hydrocarbon group or an optionally substituted hydrocarbon-oxy group, and
- n is 1,
- with the proviso that
- when R is an optionally substituted hydrocarbon group, R4 is an optionally substituted hydrocarbon-oxy group, and
- when R is an optionally substituted heterocyclic group, R4 is an optionally substituted hydrocarbon group or an optionally substituted hydrocarbon-oxy group,
- or a salt thereof.
Dependencies are inferred from the claim text.