Pyrazine derivative, and preparation method and medical use thereof
OwnerYuqiang Wang, Pei Yu +5inventors
InventorsYuqiang Wang, Pei Yu, Yewei Sun, Luchen Shan, Gaoxiao Zhang, Zaijun Zhang, Peng Yi
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Abstract
The present invention relates to a pyrazine derivative, and preparation method and medical use thereof. The pyrazine derivative can remove free radicals and suppress calcium overload and has cytoprotective effects, and can be used for the prevention and treatment of cardiovascular and cerebrovascular diseases, neurodegenerative diseases and other related diseases.
Claims11
A pyrazine derivative of formula II:
- or pharmaceutically acceptable salts thereof, wherein:
- R1 is a group selected from R′COOCH(R″), R′CH═CH, R′CONH, R′CONH(R″), wherein R′ and R″ are each a saturated or unsaturated alkyl, cycloalkyl, substituted or unsubstituted aryl or heteroaryl;
- R3 is nitronyl;
- wherein, the alkyl is a C1-C10 alkyl, the cycloalkyl is a five-membered or six-membered cycloalkyl, the aryl is a single-ring aryl, the heteroaryl is a single-ring heteroaryl;
- the substitution group is NH2, NO2, N(CH3)2, ONO2, F, Cl, Br, I, OH, OCH3, CO2H, CO2CH3, CN, aryl, or nitronyl.
A pyrazine derivative or a pharmaceutically acceptable salt thereof, the pyrazine derivative having a formula V:
- wherein:
- R5, R6, R7, R8, being the same or different, are each independently hydrogen, saturated or unsaturated alkyl, cycloalkyl, substituted or unsubstituted aryl, or heteroaryl;
- R9 and R10, being the same or different, are each independently selected from the group consisting of R′″CONH, wherein R′″ is a saturated or unsaturated alkyl, cycloalkyl, substituted or unsubstituted aryl, or heteroaryl group;
- wherein, the alkyl is a C1-C10 alkyl, the cycloalkyl is a five-membered or six-membered cycloalkyl, the aryl is a single-ring aryl, the heteroaryl is a single-ring heteroaryl;
- the substitution group is NH2, NO2, N(CH3)2, ONO2, F, Cl, Br, I, OH, OCH3, CO2H, CO2CH3, CN, aryl, or nitronyl.
The A pyrazine derivative or a pharmaceutically acceptable salt thereof, the pyrazine derivative having a formula III:
- wherein the pyrazine derivative has one of structures below:
Dependencies are inferred from the claim text.