Method for producing radiopharmaceutical composition

A method for producing a radiopharmaceutical composition containing a radioactive fluorine-labeled compound represented by the following general formula (1) or a salt thereof as an active ingredient, comprising:

• a synthesis step of obtaining a crude product of the radioactive fluorine-labeled compound from a labeling precursor compound represented by the following formula (2);
• and
• purification steps of purifying the radioactive fluorine-labeled compound, wherein
• the purification steps include:
• a first purification step using a first reverse phase solid phase extraction cartridge filled with a poly(divinylbenzene-co-N-vinylpyrrolidone) polymer;
• and
• a second purification step using a second reverse phase solid phase extraction cartridge filled with octadecylsilylated silica gel,
• wherein the first purification step includes:
• adsorbing the radioactive fluorine-labeled compound on the first reverse phase solid phase extraction cartridge;
• washing the first reverse phase solid phase extraction cartridge on which the radioactive fluorine-labeled compound has been adsorbed with a washing liquid;
• and
• eluting the radioactive fluorine-labeled compound from the first reverse phase solid phase extraction cartridge by allowing an eluent to pass through the first reverse phase solid phase extraction cartridge, wherein
• the washing liquid is an ethanol aqueous solution containing 4 to 10% by volume ethanol, and
• the eluent is an ethanol aqueous solution containing 15% by volume or more ethanol,
• wherein X represents a radioactive fluorine atom;
• wherein P1 and P2 independently or together represent a hydroxy group-protecting group, and L represents a tosyl group.