Caffeic acid derivatives and uses thereof

A compound of the formula:

• wherein:
• A1 and A2 are each independently —CH═or —N═, provided that A1 and A2 are not both —N═;
• m is 0-6;
• n is 0, 1, or 2;
• X is O, S, or NR4;
• wherein R4 is hydrogen, alkyl(C1-6), or substituted alkyl(C1-6);
• R1 and R1′ are each independently C1-8-alkyl, C3-8-cycloalkyl, —C1-8-alkanediyl—C3-8-cycloalkyl, C2-8-alkenyl, C2-8-alkynyl, C6-12-aryl, C7-12-aralkyl, or a substituted version of any of these groups, or
• R1 and R1′ are taken together and are C2-8-alkanediyl or substituted C2-8-alkanediyl;
• R2 is C2-12-heterocycloalkyl, C2-8-dialkylamino, C1-8-heteroaryl, C1-8-alkylamino, C6-8-arylamino, C1-8-alkoxy, C6-12-aryloxy, or substituted versions of any of these groups;
• and
• R3 is halo, hydrogen, hydroxy, amino, cyano or mercapto;
• or a pharmaceutically acceptable salt thereof.