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US 10,703,716 B2Granted
Antibacterial compounds and methods of use thereof
AssigneeWayne State University
InventorsFazlul H. Sarkar, Subhash Padhye, Bernhard Max Biersack, Hossein Salimnia
Life of this patent
Estimating the term…
Abstract
Disclosed herein are antibacterial compounds, pharmaceutical compositions including the antibacterial compounds, and methods of treating bacterial infections using the compounds and compositions.
Claims6
A pharmaceutical composition comprising:
- (HN34;
- 3-((3,4-difluorophenyl)(2-methyl-2,7a-dihydro-1H-indol-3-yl)methyl)-2-methyl-3a, 7a-dihydro-1H-indole), or a pharmaceutically acceptable salt or a pharmaceutically acceptable prodrug thereof;
- and
- at least one pharmaceutically acceptable excipient.
1 more element
A method of treating a bacterial infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of:
- HN18 (3-((3,4-difluorophenyl)(2,7a-dihydro-1H-indol-3-yl)methyl)-3a,7a-dihydro-1H-indole) and oxacillin or a pharmaceutical composition comprising HN18 and oxacillin, or
- HN19 ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene{4(3,4 difluoro-benzylidene)}-3,5-dione) or a pharmaceutical composition comprising HN19, or
- HN34 (3-((3,4-difluorophenyl)(2-methyl-2,7a-dihydro-1H-indol-3-yl)methyl)-2-methyl-3a,7a-dihydro-1H-indole) or a pharmaceutical composition comprising HN34, thereby treating the bacterial infection in the subject.
A method of plasmid curing a bacterium comprising contacting the bacterium with a therapeutically effective amount of:
- HN18 (3-((3,4-difluorophenyl)(2,7a-dihydro-1H-indol-3-yl)methyl)-3a,7a-dihydro-1H-indole) or a pharmaceutical composition comprising HN18, or
- HN19 ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene{4(3,4 difluoro-benzylidene)}-3,5-dione) or a pharmaceutical composition comprising HN19,
- thereby plasmid curing the bacterium.
Dependencies are inferred from the claim text.