Method for preparing nitrate ester
AssigneeIndustrial Technology Research Institute
InventorsChih-Lung Chin, Shih-Hsien Liu, Wan-Chi Chen, Kung-Lung Cheng
Life of this patent
Estimating the term…
Abstract
A method for preparing a nitrate ester is provided. The method includes providing a first solution including a compound (which has at least one hydroxyl group) and a carboxylic acid having 2-5 carbon atoms; providing a second solution including nitric acid, acetic anhydride, and acetic acid; and transferring the first solution and the second solution to a microreactor, obtaining a nitrate ester after a residence time. In particular, the ratio of the weight of nitric acid to the total volume of the acetic anhydride and acetic acid is 1:1 to 1:3.5. The ratio of the molar amount of nitric acid to the hydroxyl group equivalent of the compound is from 1:1 to 15:1.
Claims9
A method for preparing nitrate ester, comprising:
- providing a first solution, wherein the first solution consists of a compound and a carboxylic acid having 2-5 carbon atoms, wherein the compound is isosorbide, glycerin, pentaerythritol, mannitol, trimethylolpropane, or 3-monochloro-1,2-propanodiol, and wherein the carboxylic acid having 2-5 carbon atoms is acetic acid, propionic acid, butyric acid, or pentanoic acid;
- providing a second solution, wherein the second solution consists of nitric acid, acetic anhydride and acetic acid, wherein the ratio of the weight of nitric acid to the total volume of the acetic anhydride and acetic acid is 1:1 to 1:3.5;
- transferring the first solution and the second solution to a microreactor to form a mixture, and obtaining a nitrate ester after a residence time,
- wherein the ratio of the molar amount of nitric acid in the mixture to the hydroxyl group equivalent of the compound in the mixture is from 1:1 to 15:1,
- and wherein the nitrate ester is isosorbide dinitrate, glyceryl trinitrate, pentaerythritol tetranitrate, mannitol hexanitrate, propatyl trinitrate, or clonitrate.
Dependencies are inferred from the claim text.