Treprostinil derivatives and compositions and uses thereof

A compound of Formula (I):

• wherein:
• R1 and R2 independently are hydrogen,
• wherein:
• R6 in each occurrence independently is hydrogen, R3, —C(═O)R3, —C(═O)OR3 or —C(═O)NR9R10;
• R3 in each occurrence independently is alkyl, haloalkyl, -alkylaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, each of which may optionally be substituted;
• R9 and R10 in each occurrence independently are hydrogen, alkyl, -alkylaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl;
• or
• R9 and R10 and the nitrogen atom to which they are connected form a heterocyclic or heteroaryl ring;
• j in each occurrence independently is an integer from 0 to 4;
• and
• t in each occurrence independently is an integer from 1 to 9;
• with the proviso that:
• both R1 and R2 are not hydrogen;
• and
• R1 or R2 is not
• or a pharmaceutically acceptable salt, solvate, hydrate, clathrate, polymorph or stereoisomer thereof.