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US 10,703,701 B2Granted
Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
AssigneePTC Therapeutics, Inc.
InventorsAndrew W. Hinman, Steven J. Richards
Life of this patent
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Abstract
Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are tocopherol quinone derivatives. Further disclosed are compounds, compositions, and methods for treatment of, or prophylaxis against, radiation exposure.
Claims23
A compound of the formula I:
- or the hydroquinone form thereof;
- wherein:
- R1 and R2 are independently C1-C10 alkyl;
- R3 is C1-C6 alkyl;
- R4 is C1-C12 n-alkyl and R5 is —OCH3, —OCF3, or —OCH2CF3, wherein R5 is attached to R4 at any chemically possible location on the C1-C12 n-alkyl group;
- or
- R4 is C6-C12 alkyl and R5 is —CF3, wherein R5 is attached to R4 at any chemically possible location on the C6-C12 alkyl group;
- or a salt, a stereoisomer, or mixture of stereoisomers thereof;
- with the proviso that the compound is not
6 more elements
Dependencies are inferred from the claim text.