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US 10,702,719 B2Granted
Histotripsy treatment of hematoma
AssigneeUniversity of Washington
InventorsTatiana Khokhlova, Thomas J. Matula, Wayne L. Monsky, Yak-Nam Wang
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Abstract
Methods for treating an extravascular hematoma in a patient can include liquefying a first portion of the extravascular hematoma by applying a first series of focused acoustic pulses to the extravascular hematoma at a first frequency; and liquefying a second portion of the extravascular hematoma by applying a second series of focused acoustic pulses to the extravascular hematoma at a second frequency. Liquefied remains of the extravascular hematoma can be aspirated from the patient following liquefaction and disruption.
Claims17
A method for treating an extravascular hematoma in a patient, the method comprising:
- applying a first series of focused acoustic pulses to debulk a first volume corresponding to an interior of the extravascular hematoma by moving a focal region of the first series of focused acoustic pulses through the first volume;
- after debulking the first volume, applying a second series of focused acoustic pulses to liquefy a second volume of the interior of the extravascular hematoma by moving a second focal region of the second series of focused acoustic pulses through the second volume, the second volume comprising an unliquefied remainder of the extravascular hematoma;
- and
- monitoring a first position of the first focal region of the first series of focused acoustic pulses by detecting one or more bubbles induced by the first series of focused acoustic pulses or monitoring a second position of the second focal region of the second series of focused acoustic pulses by detecting one or more bubbles induced by the second series of focused acoustic pulses;
- determining that the extravascular hematoma is liquefied at the first position by detecting one or more anechoic regions in the extravascular hematoma at the first position;
- repositioning the first focal region or second focal region of focused acoustic pulses based in part on detecting the one or more anechoic regions;
- and
- determining a suitable aspiration site for aspirating a liquefied portion of the extravascular hematoma based in part on detecting the one or more anechoic regions;
- and
- aspirating at least some of the first and second volumes of the extravascular hematoma from the patient.
7 more elements
A system for treating an extravascular hematoma in a patient, the system comprising:
- an acoustic emitter configured to emit high intensity focused ultrasonic energy in a series of focused acoustic pulses, the focused acoustic pulses having pulse durations in at least one of a first range and a second range, the first range being sufficiently long to generate a vapor bubble;
- and the second range being sufficiently short that focal heating does not create a vapor bubble;
- a sensor configured to detect ultrasound reflection;
- and
- a processor and a memory containing instructions, the instructions operable to cause the processor to:
- cause the acoustic emitter to generate a first series of acoustic pulses having durations in the first range, the first series being configured to debulk a first volume corresponding to an interior of the extravascular hematoma by moving a focal region of the first series of focused acoustic pulses through the first volume;
- and
- cause the acoustic emitter to generate a second series of acoustic pulses having durations in the second range, the second series being configured to liquefy a nonliquid remnant of the extravascular hematoma, by moving a second focal region of the second series of focused acoustic pulses through a second volume, the second volume comprising an unliquefied remainder of the extravascular hematoma;
- monitor a first position of the first focal region of the first series of focused acoustic pulses by detecting, via the sensor, one or more bubbles induced by the first series of focused acoustic pulses or monitor a second position of the second focal region of the second series of focused acoustic pulses by detecting, via the sensor, one or more bubbles induced by the second series of focused acoustic pulses;
- determine that the extravascular hematoma is liquefied at the first position by detecting, via the sensor, one or more anechoic regions in the extravascular hematoma at the first position;
- repositioning the first focal region or second focal region of focused acoustic pulses based in part on detecting the one or more anechoic regions;
- and
- determine a suitable aspiration site for aspirating a liquefied portion of the extravascular hematoma based in part on detecting the one or more anechoic regions.
10 more elements
Dependencies are inferred from the claim text.