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US 10,702,627 B2Granted
Solid forms for tissue repair
AssigneeCartiheal (2009) Ltd.
InventorsNir Altschuler, Razi Vago
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Abstract
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
Claims32
A scaffold for tissue repair, said scaffold consisting essentially of two phases wherein:
- a first phase of said two phases comprises solid coral, aragonite or calcite and a biocompatible polymer,
- wherein said first phase further comprises a series of hollows along a longitudinal axis in said first phase, and wherein said biocompatible polymer penetrates to within said hollows;
- and
- a second phase of said two phases that comprises a solid coral, aragonite or calcite,
- wherein said scaffold is seeded with cells that comprise bone marrow cells, precursor cells derived from adipose tissue, or a combination thereof and wherein said first phrase or said second phase of said scaffold comprises said solid form of aragonite or calcite.
2 more elements
Dependencies are inferred from the claim text.