Radiobacteria for therapy of cancer
AssigneeAlbert Einstein College of Medicine
InventorsEkaterina Dadachova, Claudia Gravekamp, Arturo Casadevall
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Abstract
A method of treating a tumor in a subject, or reducing or preventing metastasis of a tumor in a subject, is provided comprising administering to the subject an amount of a bacteria labelled with, or comprising, one or more radionuclides so as to treat the tumor in the subject, or so as to reduce or prevent metastasis of the tumor in the subject. Radiobacteria-containing compositions and pharmaceutical compositions are also provided.
Claims9
A method of treating metastases of a prostate tumor in a subject, comprising administering to the subject an amount of attenuated Listeria monocytogenes labelled or loaded with 32P or 188Re (radiolisteria) effective to selectively accumulate the radiolisteria in the metastases of the prostate tumor as compared to in the prostate tumor, so as to treat the metastases of the prostrate tumor in the subject, wherein the radiolisteria is administered to the subject once a day for at least seven days.
A method of treating metastases of a pancreatic tumor in a subject, comprising administering to the subject an amount of attenuated Listeria monocytogenes labelled or loaded with 32P or 188Re (radiolisteria) effective to selectively accumulate the radiolisteria in the metastases of the pancreatic tumor as compared to in the pancreatic tumor, so as to treat the metastases of the pancreatic tumor in the subject, wherein the radiolisteria is administered to the subject once a day for at least seven days.
Dependencies are inferred from the claim text.