Factor VIII zwitterionic polymer conjugates

A compound having the following formula:

• R1-R2R3)s;
• wherein s is 1-20;
• R1 is selected from the group consisting of —NH2, —OH, and —SH;
• R2 is selected from the group consisting of unsubstituted alkyl, unsubstituted alkylene, unsubstituted alkoxy, carboxyalkyl, haloalkyl, cycloalkyl, cyclic alkyl ether, alkenyl, alkenylene, alkynyl, alkynylene, cycloalkylene, heterocycloalkyl, heterocycloalkylene, aryl, arylene, arylene-oxy, heteroaryl, amino, amido and a combination thereof;
• and
• R3 is
• wherein R4, R5, and R6 are the same or different and are selected from the group consisting of:
• and
• wherein Z is —NCS, —F, —Cl, —Br, —I, or polymer, the polymer is synthesized with a monomer selected from the group consisting of:
• wherein
• R7 is H or C1-6 alkyl, ZW is a zwitterion, and t is 1 to 6.