Abuse-deterrent pharmaceutical compositions
AssigneeG.L. Pharma GmbH
InventorsGeorg Guebitz, Katrin Greimel, Martin Brandauer, Daniela Huber, Klaus Bleymaier, Wolfgang Kroutil, Doris Lechner, Christof Wachter, Harald Wagner, Heimo Winkler
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Abstract
Disclosed are pharmaceutical compositions comprising oxycodone and an oxycodone-processing enzyme, wherein oxycodone is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on oxycodone.
Claims12
A pharmaceutical composition comprising oxycodone or a pharmaceutically acceptable salt thereof and an oxycodone-processing enzyme, wherein oxycodone is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on oxycodone,
- wherein the oxycodone-processing enzyme is selected from 3-alpha-hydroxysteroid 3-dehydrogenase, cytochrome P450, copper-dependent monooxygenases, the CYP2C subfamily;
- CYP2D6;
- unspecific monooxygenase, Codeine 3-0-demethylase, CYP1-3, horseradish peroxidase, carbonyl reductase, flavin-dependent monooxygenases, microsomal epoxide hydrolase, cofactor independent monooxygenase, epoxide hydratase, soluble epoxide hydrolase, UDP-glucuronosyltransferase, bilirubin-glucuronoside glucuronosyltransferase, ac(et)yltransferase, sulfotransferases, and CoA-transferase.
Dependencies are inferred from the claim text.