Lipid nanocapsules comprising a retinoid, nanodispersion and composition containing the same, process for preparing the same and use thereof in dermatology

A composition comprising a nanodispersion in a pharmaceutically acceptable vehicle, the nanodispersion comprising lipid nanocapsules dispersed in a hydrophilic phase, wherein the lipid nanocapsules comprise:

• an oily inner phase and a non-polymeric envelope obtained from at least one surfactant chosen from amphiphilic lipids, wherein the oily inner phase consists of a fatty substance that is liquid or semiliquid at room temperature and at least one retinoid as an irritant active principle dissolved in the fatty substance, wherein the nanocapsule does not comprise any organic solvent of alcoholic type, wherein the surfactant is a lecithin with a weight amount of hydrogenated phosphatidylcholine of greater than 85%, wherein the fatty substance comprises at least one oily solvent, and wherein the ratio of the inner oily phase to the amount of lecithin is from 5/1 to 7/1;
• and
• wherein the composition comprises, on a weight basis relative to the total weight of the composition,
• 0.01% to 10% of the surfactant,
• 0.1% to 50% of the fatty substance, and
• 0.00001% to 0.3% of at least 3″-tert-butyl-4′-(2-hydroxyethoxy)-4″-pyrrolidin-1-yl[1,1′;3′,1″]-terphenyl-4-carboxylic acid as the retinoid.