Formulation of a peptide vaccine
AssigneeISA Pharmaceuticals B.V.
InventorGwenn Eveline Mulder
Life of this patent
Estimating the term…
Abstract
The invention relates to a novel reconstitution composition, a pharmaceutical composition and kit of parts comprising said reconstitution composition. The invention further relates to a method of treatment using said pharmaceutical composition and/or the pharmaceutical composition for use as a medicament. Also provided is a method for reconstituting dried peptides and a method for preparing a pharmaceutical composition using the reconstitution composition of the invention.
Claims22
A reconstitution composition for reconstituting dried peptides, comprising:
- (a) about 60-80% v/v aqueous solution comprising an organic acid at a concentration of 0.05 to 0.25M, wherein the organic acid prevents intermolecular disulfide bond formation at the concentration specified, (b) about 5-10% v/v propylene glycol, (c) about 10-20% v/v lower alcohol, and (d) about 5-10% v/v non-ionic hydrophilic surfactant.
The pharmaceutical composition according to 31, wherein the composition comprises:
- (a) about 1-2 mg/mL peptides in about 40-60% v/v of the reconstitution composition, and
- (b) about 40-60% v/v of Montanide ISA 51VG,
- wherein the peptides are a mixture of different peptides represented by SEQ ID NO:
- 1-5 or SEQ ID NO:
- 1-6 or SEQ ID NO:
- 7-13.
Dependencies are inferred from the claim text.