Dried saponin liposomal composition
AssigneeGlaxosmithkline Biologicals SA
InventorsDominique Ingrid Lemoine, Nicolas Moniotte
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Abstract
Described herein is the formulation of immunogenic or vaccine compositions comprising neutral lipid liposome based adjuvants, where the composition is suitable for lyophilisation. In particular, the invention relates to lyophilised forms of such immunogenic or vaccine compositions wherein both the immunogen or vaccine antigen and the adjuvant are present in one and the same vial, as well as to the formulation and manufacture of lyophilised forms of such immunogenic or vaccine composition.
Claims22
A dried composition comprising an adjuvant comprising (a) a saponin in a liposomal formulation comprising liposomes containing a neutral lipid and a sterol and (b) a cryoprotectant that is an amorphous sugar, wherein the dried composition has been dried under reduced pressure from a liquid mixture comprising the adjuvant and the cryoprotectant.
Dependencies are inferred from the claim text.