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US 10,702,587 B2Granted
Angiopoietin-like protein 8 polypeptide fragments and compositions thereof
AssigneeNGM Biopharmaceuticals, Inc.
InventorsZhonghao Liu, Xunshan Ding
Life of this patent
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Abstract
Methods and compositions for reducing one or more of triglyceride levels, total cholesterol levels and LDL cholesterol levels in a subject are provided. The methods include administering a fragment of ANGPTL8 to a subject having or at risk of developing elevated triglyceride levels, elevated total cholesterol levels and/or elevated LDL cholesterol levels.
Claims23
A polypeptide comprising amino acids 80-198 of SEQ ID NO:
- 1, wherein the polypeptide lacks amino acids 21-70 of SEQ ID NO:1.
A polypeptide comprising amino acids 22-139 of SEQ ID NO:16, wherein the polypeptide lacks amino acids 21-80 of SEQ ID NO:1.
Dependencies are inferred from the claim text.