Method for preparing a bone protein preparation and a bone protein preparation
AssigneeBbs-Bioactive Bone Substitutes Oyj
InventorsHanna Tölli, Juha-Matti Närhi, Harri Lumme, Elli Birr, Oili Hietala, Mikko Viitanen, Merja Haikola, Pekka Jalovaara, Bo Kenneth Sandström
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Abstract
The present invention provides a method for preparing a bone protein preparation which contains for example growth factors. The present invention also provides a bone protein preparation obtained by the method and paste, putty, pellet, disc, block, granule, osteogenic device or pharmaceutical composition containing said bone protein preparation.
Claims23
A bone preparation comprising a reindeer bone protein extract, polyethylene glycol, glycerol, and calcium salt granules, wherein the reindeer bone protein extract comprises Matrix Gla protein, a species of SPP-24 (secreted phosphoprotein), which migrates on SDS-PAGE at approximately 15 kDa, BMP-2, BMP-7, and TGF-beta 1.
A reindeer bone protein guanidine hydrochloride extract having a pH measured between 3.9-4.5, wherein said reindeer bone protein guanidine hydrochloride extract comprises Matrix Gla protein, a species of SPP-24 (secreted phosphoprotein), which migrates on SDS-PAGE at approximately 15 kDa, BMP-2, BMP-7 and TGF-beta 1.
A reindeer bone protein guanidine hydrochloride extract comprising a species of SPP-24 (secreted phosphoprotein), which migrates on SDS-PAGE at approximately 15 kDa.
Dependencies are inferred from the claim text.