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US 10,702,578 B2Granted
Ophthalmic compositions of cyclosporine
AssigneeShilpa Medicare Limited
InventorsVara Prasad Rangabhatla Gunneswara Subramanya, Sandeep Kalepu, Ratna Phani Ayalasomayajula
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Abstract
The present invention relates to the ophthalmic composition comprising from about 0.03% to about 2% by weight of cyclosporine, from about 0.05% to about 5% by weight of tamarind seed polysaccharide and a pharmaceutically acceptable carrier. Further the invention relates to the process for preparation of ophthalmic compositions and its use for the treatment of dry eye.
Claims5
An ophthalmic composition consisting of
- (a) about 0.03% to about 2% by weight of cyclosporine,
- (b) about 0.05% to about 5% by weight of tamarind seed polysaccharide and
- (c) at least one pharmaceutically acceptable carrier selected from group consisting of surfactants, cellulose polymers, solvents, tonicity adjusting agents, buffers, pH adjusting agents and preservatives.
An ophthalmic composition consisting of
- (a) about 0.03% to about 2% by weight of cyclosporine,
- (b) about 0.05% to about 5% by weight of tamarind seed polysaccharide,
- (c) about 0.05% to about 5% by weight of hydroxypropyl methylcellulose,
- (d) about 0.05% to about 2% by weight of polysorbate 80,
- (e) about 0.3% to about 2% by weight of polyoxyl 40 hydrogenated castor oil,
- (f) about 0.1% to about 5% by weight of ethanol,
- (g) at least one pharmaceutically acceptable carrier selected from tonicity adjusting agent, buffer, pH adjusting agent, preservative and
- (h) water.
5 more elements
An ophthalmic composition consisting of
- (a) about 0.07% by weight of cyclosporine,
- (b) about 0.8% by weight of tamarind seed polysaccharide,
- (c) about 0.9% by weight of polysorbate 80,
- (d) about 0.5% by weight of polyoxyl 40 hydrogenated castor oil,
- (e) about 0.5% by weight of hydroxypropyl methylcellulose,
- (f) about 0.5% by weight of ethanol,
- (g) at least one pharmaceutically acceptable carrier selected from tonicity adjusting agent, buffer, pH adjusting agent, preservative and
- (h) water,
- wherein pH of the composition is of about 6.0 to about 7.5.
6 more elements
Dependencies are inferred from the claim text.