Combination therapies using cyclosporine and aromatic cationic peptides
AssigneeStealth BioTherapeutics Inc.
InventorD. Travis Wilson
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Abstract
The invention provides compositions and methods for preventing or treating an ischemia-reperfusion injury, such as occurs during acute myocardial infarction and organ transplant in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof, and one or more additional active agents such as cyclosporine.
Claims14
A method for treating ischemia and/or reperfusion injury in a subject in need thereof, the method comprising administering simultaneously, separately or sequentially an effective amount of (i) an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof, wherein the aromatic-cationic peptide is selected from the group consisting of:
- Tyr-D-Arg-Phe-Lys-NH2;
- 2′,6′-Dmt-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2;
- 2′,6′-Dmp-D-Arg-Phe-Lys-NH2;
- and D-Arg-2′,6′-Dmt-Lys-Phe-NH2 and (ii) an additional active agent comprising a functional analogue of cyclosporine.
A pharmaceutical composition comprising (i) an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof, wherein the aromatic-cationic peptide is selected from the group consisting of:
- Tyr-D-Arg-Phe-Lys-NH2;
- 2′,6′-Dmt-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2;
- 2′,6′-Dmp-D-Arg-Phe-Lys-NH2;
- and D-Arg-2′,6′-Dmt-Lys-Phe-NH2, and (ii) an additional active agent comprising a functional analogue of cyclosporine.
A composition comprising:
- an (i) an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof, wherein the aromatic-cationic peptide is selected from the group consisting of:
- Tyr-D-Arg-Phe-Lys-NH2;
- 2′,6′-Dmt-D-Arg-Phe-Lys-Nth;
- Phe-D-Arg-Phe-Lys-NH2;
- 2′,6′-Dmp-D-Arg-Phe-Lys-NH2;
- and D-Arg-2′,6′-Dmt-Lys-Phe-NH2, and (ii) an additional active agent comprising a functional analogue of cyclosporine, wherein the aromatic-cationic peptide is linked to the additional active agent by a linker.
Dependencies are inferred from the claim text.