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US 10,702,556 B2Granted
Compositions and methods for inducing angiogenesis
AssigneeMinovia Therpautices Ltd.
InventorsNatalie Yivgi-Ohana, Uriel Halavee, Shmuel Bukshpan
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Abstract
The present invention relates to compositions and methods of inducing angiogenesis and methods of treating a pathology that would benefit from angiogenesis by use of a composition comprising partially purified intact mitochondria and/or ruptured mitochondria derived therefrom.
Claims12
A method of inducing angiogenesis in a tissue in vivo comprising:
- thawing a frozen composition, wherein the composition comprises partially purified mitochondria, wherein the mitochondria include intact and ruptured mitochondria;
- wherein the weight of the partially purified mitochondria constitutes between 20-80% of the combined weight of the composition relative to other sub-cellular fractions in the composition;
- wherein the mitochondria are at least as functional as control mitochondria that have not undergone a freeze-thaw cycle;
- wherein the mitochondria are derived from a mammalian cell;
- and wherein the composition comprises a saccharide;
- and
- administering to the tissue a therapeutically effective amount of the thawed composition,
- thereby inducing angiogenesis in a tissue as compared with administration of a control vehicle.
5 more elements
A method for treating a subject afflicted with a pathology which would benefit from angiogenesis comprising:
- (a) thawing a frozen composition, wherein the composition comprises partially purified mitochondria, wherein the mitochondria include intact and ruptured mitochondria;
- wherein the weight of the partially purified mitochondria constitutes between 20-80% of the combined weight of the composition relative to other sub-cellular fractions in the composition;
- wherein the mitochondria are at least as functional as control mitochondria that have not undergone a freeze-thaw cycle;
- and wherein the composition comprises a saccharide;
- and
- (b) administering a therapeutically effective amount of the thawed composition to a tissue afflicted with a pathology which would benefit from angiogenesis, thereby treating the subject afflicted with the pathology which would benefit from angiogenesis as compared to a vehicle treated control.
3 more elements
Dependencies are inferred from the claim text.