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US 10,702,555 B2Granted
Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof
AssigneeNeuralstem, Inc.
InventorsThomas Hazel, Karl K. Johe
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Abstract
The present disclosure provides a human neural stem cell comprising an exogenous polynucleotide coding for a growth factor such as IGF-1. Also disclosed are methods of using the human neural stem cells for the treatment of neurodegenerative diseases or disorders including, for example, ALS.
Claims2
A stable human neural stem cell comprising a vector containing an exogenous polynucleotide coding for insulin-like growth factor 1 (IGF-1) isoform 4 wherein the human neural stem cell is expandable for more than sixty cell doublings without undergoing differentiation.
Dependencies are inferred from the claim text.