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US 10,702,554 B2Granted
Extracellular matrix from pluripotent cells
AssigneeSanBio, Inc.
InventorIrina Aizman
Life of this patent
Estimating the term…
Abstract
Isolated extracellular matrix from marrow adherent stromal cells and their descendents, which stimulates the growth and survival of a number of different neural cell types, is provided, along with methods for preparation and uses.
Claims7
A method for producing an isolated extracellular matrix, the method comprising culturing differentiation-restricted descendents of marrow adherent stromal cells (DRCs) on a culture surface and isolating the extracellular matrix deposited on the culture surface;
- wherein the DRCs are produced by transfection of a culture of marrow adherent stromal cells (MASCs) with a nucleic acid comprising sequences encoding a Notch intracellular domain,
- further wherein the isolated extracellular matrix stimulates the growth of neural cells.
Dependencies are inferred from the claim text.