SiRNA of human IL-6 and recombinant expression CAR-T vector and their construction methods and applications
AssigneeShanghai Unicar-Therapy Bio-Medicine Technology Co., Ltd
InventorsLei Yu, Liqing Kang, Zhou Yu
Life of this patent
Estimating the term…
Abstract
Provided are a siRNA of the human interleukin 6, a recombinant expression CAR-T vector, and a construction method and a use thereof. The siRNA can be used in the treatment of acute B-cell lymphocytic leukemia with CAR19-T for eliminating or alleviating the symptoms of cytokine release syndrome (CRS), and can also be used for alleviating the CRS symptoms caused by treating tumours with CAR-T and even can also be used for alleviating CRS caused by other types of treatment.
Claims20
A pair of siRNAs of human IL-6, wherein, the siRNAs have nucleotide sequences selected from the group consisting of
- a. SEQ ID NO:
- 43 and SEQ ID NO:
- 44;
- b. SEQ ID NO:
- 45 and SEQ ID NO:
- 46;
- c. SEQ ID NO:
- 47 and SEQ ID NO:
- 48;
- d. SEQ ID NO:
- 49 and SEQ ID NO:
- 50;
- e. SEQ ID NO:
- 51 and SEQ ID NO:
- 52;
- f. SEQ ID NO:
- 53 and SEQ ID NO:
- 54;
- g. SEQ. ID NO:
- 55 and SEQ ID NO:
- 56;
- and
- h. SEQ ID NO:
- 57 and SEQ ID NO:
- 58.
Dependencies are inferred from the claim text.