Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse
AssigneeFred Hutchinson Cancer Research Center
InventorMatthias Stephan
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Abstract
The present disclosure provides compositions and methods for the delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse. The compositions comprise (i) a structure comprising an injectable polymer or scaffold comprising pores; (ii) lymphocytes disposed within the structure, (iii) at least one lymphocyte-adhesion moiety associated with the structure; and (iv) at least one lymphocyte-activating moiety associated with the structure, and optionally an immune stimulant.
Claims9
An alginate polymer scaffold coated with a synthetic collagen-mimetic peptide comprising SEQ ID NO:
- 2, wherein the scaffold houses:
- porous silica microparticles with a pore diameter of about 100 Å and wherein the microparticles are (a) coated with anti-CD3 antibodies and anti-CD28 antibodies and (b) loaded with interleukin 15.
A composition comprising (i) an injectable alginate polymer or an implantable alginate polymer scaffold comprising pores;
- and (ii) SEQ ID NO:
- 2, anti-CD3 antibodies, anti-CD28 antibodies, and interleukin 15.
Dependencies are inferred from the claim text.