Compositions for treatment of arthritis
OwnerAhmed Al-Qahtaniinventor
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Abstract
The present invention relates to compositions to treat inflammation, and more particularly, an injectable comprising hyaluronic acid and cell culture medium conditioned by cells grown in two-dimensional culture. Also included are methods of using such compositions and kits comprising the injectable therein.
Claims20
An injectable composition for treating osteoarthritis, comprising non-crosslinked hyaluronic acid (HA), wherein said HA has a molecular weight of about 300,000 daltons, and a conditioned medium or extract or concentrate thereof, from cultured substantially homogenous fibroblast cells, wherein said conditioned medium is generated by incubating a nutrient medium with said cells in two-dimensional culture under conditions adapted to promote secretion of at least one growth factor into the nutrient medium, and wherein said at least one growth factor is present in said conditioned medium or extract or concentrate thereof in an amount sufficient to treat osteoarthritis symptoms, and wherein said composition does not cause inflammation at a therapeutically effective dose.
Dependencies are inferred from the claim text.