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AssigneeNational University Corporation Tokyo Medical and Dental University
InventorsEmi Nishimura, Hiroyuki Matsumura
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The present invention provides novel compositions for suppressing or improving hair loss, and compositions for suppressing or improving graying. More specifically, it provides agents that stabilize type XVII collagen expression, preferably agents that suppress the degradation of type XVII collagen by ELANE inhibitors and such, and compositions comprising a DNA repair-promoting agent or a DNA damage-suppressing agent as an active ingredient. Advantageous suppressive effects of hair loss and graying can be obtained when a composition comprising as an active ingredient a suppressive agent of type XVII collagen degradation such as an ELANE inhibitor is administered to a mammal. For the ELANE inhibitors, suppressive agents of type XVII collagen degradation and DNA repair-promoting agents, low-molecular compounds, polypeptides, proteins, antibodies, or nucleic acid medicine such as antisense oligos or siRNAs may be used. A method of screening for effective substances for suppression of hair loss and graying is also provided.
A method for treating alopecia in a mammal, comprising administering to the mammal an agent selected from the group consisting of a suppressive agent of type XVII collagen degradation and a stabilizing agent of type XVII collagen expression.
A method for treating alopecia in a mammal, comprising administering to the mammal a substance selected from the group consisting of Gigartina tenella extract, Saraca dives extract, Cudrania pubescens extract, Taxodium distichum extract, Ludwigia octovalis extract, Deutzianthus tonkinensis extract, Alchornea trewioides extract, Berchemia polyphylla extract, Glochidion puberum extract, Sassafras tzumu extract, Cinchona extract, comfrey extract, coffea extract, pueraria root extract, burdock extract, coptis root extract, Sophora angustifolia extract, Chlorella vulgaris extract, Lavandula vera extract, Oenothera biennis extract, rose extract, Gynostemma extract, Rabdosia japonica extract, lamium album extract, carrot extract, Japanese linden extract, Sanguisorba officinalis, lotus extract, tea extract, and okra extract.
A method for treating alopecia in a human subject, comprising administering at least one of sivelestat sodium hydrate and apocynin to the human subject.
Dependencies are inferred from the claim text.