Compositions and methods for reducing muscle contraction
AssigneeBattelle Memorial Institute
InventorsBrian L. Burback, Jessica Catherine Bright, Jerry D. Johnson
Life of this patent
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Abstract
Disclosed herein are methods of reducing muscle contraction in a diaphragm or peripheral muscle(s) of a patient sufficient to permit a surgical procedure. The methods may comprise the step of administering an oxime or pharmaceutically acceptable salt thereof to a subject in need thereof in an amount sufficient to achieve said reduced muscle contraction/neuromuscular blockade. Kits and articles of manufacture comprising a container having a label and a composition are also disclosed.
Claims9
A method of inducing neuromuscular blockade via modulation of a nicotinic receptor in an individual in need thereof, comprising the step of administering an oxime or pharmaceutically acceptable salt thereof, an analgesic, an anti-salivation agent, and an anesthetic to said individual, wherein said oxime or pharmaceutically acceptable salt thereof is administered in an amount that achieves cessation of a muscle contraction at a site selected from one or both of diaphragm muscle and peripheral muscle.
Dependencies are inferred from the claim text.