MU opioid receptor modulators

A compound having the formula:

• wherein,
• W is O or S;
• Ring A is independently R3-substituted or unsubstituted phenyl or R3-substituted or unsubstituted pyridinyl;
• Ring B is independently R4-substituted or unsubstituted thienyl, R4-substituted or unsubstituted phenyl, R4-substituted or unsubstituted benzothienyl, R4-substituted or unsubstituted naphthyl, R4-substituted or unsubstituted benzofuranyl, R4-substituted or unsubstituted furanyl, R4-substituted or unsubstituted pyrrolyl-2,5-dione, or R4-substituted or unsubstituted 2,3-dihydro-1H-indenyl;
• L1 is independently a bond or an unsubstituted (C1-C5) alkylene;
• L2 is an unsubstituted (C1-C5) alkylene;
• R1 and R2 are independently hydrogen,
• halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, NHC═(O)NHNH2, NHC═(O)NH2, —NHSO2H, —NHC═(O)H, —NHC(O)OH, —NHOH, —CHF2, —CH2F, —OCF3, —OCHF2, substituted or unsubstituted (C1-C5) alkyl, substituted or unsubstituted 2 to 5 membered heteroalkyl, substituted or unsubstituted (C3-C6) cycloalkyl, or substituted or unsubstituted 3 to 6 membered heterocycloalkyl;
• or R1 and R2 may optionally be joined to form a substituted or unsubstituted 3 to 6 membered heterocycloalkyl or substituted or unsubstituted 5 to 6 membered heteroaryl;
• L1 and R1 may optionally be joined to form a substituted or unsubstituted 4 to 8 membered heterocycloalkyl;
• L1 and R2 may optionally be joined to form a substituted or unsubstituted 4 to 8 membered heterocycloalkyl;
• L3 is —N(R6)—;
• R3 is independently hydrogen, —CX3, CHX2, CH2X, —CN, —SOnR10, —SOvNR7R8, —NHNR7R8, —ONR7R8, —NHC═(O)NHNR7R8, —NHC═(O)NR7R8, —N(O)m, —NR7R8, —C(O)R9, —C(O) —OR9, —C(O)NR7R8, —OR10, —NR7SO2R10, —NR7C═(O)R9, —NR7C(O)OR9, —NR7OR9, —CHX2, —CH2X, —OCX3, —OCHX2, substituted or unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• or two adjacent R3 substituents may optionally be joined to form an unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R4 is independently hydrogen, halogen, —CXa3, —CN, —SOn1R14, —SOv1NR11R12, —NHNR11R12, —ONR11R12, —NHC═(O)NHNR11R12, —NHC═(O)NR11R12, —N(O)m1, —NR11R12, —C(O)R13, —C(O) —OR13, α, —OR14, —NR11SO2R14, —NR14C═(O)R13, —NR11C(O)OR13, —NR11OR13, —CHX2, —CH2X, —OCX3, —OCHX2, oxo, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• or two adjacent R4 substituents may optionally be joined to form an unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R5 is independently hydrogen, —CF3, —CN, —COOH, —CONH2, —CHF2, —CH2F, substituted or unsubstituted (C1-C5) alkyl, or substituted or unsubstituted 2 to 5 membered heteroalkyl;
• R6 is hydrogen, —CF3, —CN, —COOH, —CONH2, —CHF2, —CH2F, substituted or unsubstituted (C1-C5) alkyl, or substituted or unsubstituted 2 to 5 membered heteroalkyl
• R10 is independently hydrogen,
• halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2, —NHC═(O)NH2, —NHSO2H, —NHC═(O)H, —NHC(O)OH, —NHOH, —CHF2, —CH2F, OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or R7 and R8 substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R7 and R8 are independently hydrogen,
• halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2—NHC═(O)NH2, —NHSO2H, —NHC═(O)H, —NHC(O)OH, —NHOH, —CHF2, —CH2F, OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted heteroaryl,
• R9 is independently hydrogen,
• halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2, —NHC═(O)NH2, —NHSO2H, —NHC═(O)H, —NHC(O)OH, —NHOH, —CHF2, —CH2F, OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R11, R12, R13, and R14 are independently hydrogen, halogen,
• —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2, —NHC═(O)NH2, —NHSO2H, —NHC═(O)H, —NHC(O)OH, —NHOH, —CHF2, —CH2F, —OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R11 and R12 substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• m, m1, v, and v1 are independently 1 or 2;
• n and n1 are independently an integer from 0 to 4;
• and
• X and Xa are independently —Cl, —Br, —I, or —F.