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US 10,702,497 B2Granted
Use of acyl-homoserine lactone derivatives as anti-thrombotic agents
AssigneeThe University of Toledo
InventorsRandall G. Worth, Glenn R. Westphal, Brenton R. Keeley, Leah M. Wuescher
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Abstract
Uses of acyl-homoserine lactone compounds are described. In particular, uses of acyl-homoserine lactone compounds as anti-thrombotic agents, to inhibit platelets from becoming hypersensitive, and/or to prevent thrombosis, are described.
Claims6
A method of inhibiting platelets from becoming hypersensitive to thrombin, the method comprising:
- administering an effective amount, at a concentration of about 200 μM or less, of an acyl-homoserine lactone compound to a patient in need thereof;
- and inhibiting platelets in the patient from becoming hypersensitive;
- wherein the acyl-homoserine lactone is compound 10C-AHL having Formula III:
Dependencies are inferred from the claim text.