Treatment of nervous system disorders using combinations of RXR agonists and thyroid hormones

A method of treating multiple sclerosis, the method comprising administering to an individual in need thereof a therapeutically effective amount of a RXR agonist and a thyroid hormone, wherein administration of the combination of the RXR agonist and the thyroid hormone treats the multiple sclerosis in the individual, wherein the RXR agonist is 3,7-dimethyl-6(S),7(S)-methano,7-[1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphth-7-yl]2(E),4(E) heptadienoic acid, and has the structure of formula III:

• and wherein the combination of RXR agonist and thyroid hormone causes a greater improvement in the multiple sclerosis than the RXR agonist or thyroid hormone alone;
• the method further comprising administration of a neurotrophic factor, or neurotrophic factor mimetic.