Systems and methods for the fabrication of tablets, including pharmaceutical tablets
AssigneeMassachusetts Institute of Technology
InventorsAllan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, David Brancazio, Juan Guillermo Osorio Caicedo
Life of this patent
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Abstract
Systems and methods for fabricating ingestible pharmaceutical tablets are provided. Certain of the systems and methods described herein are capable of manufacturing tablets of different dosages without the need to fluidically connect or disconnect unit operations when switching from a tablet having a first dosage to a tablet having a second, different dosage. Certain of the systems and methods described herein are capable of manufacturing compositionally tablets, e.g., tablets with different active pharmaceutical ingredients (APIs).
Claims29
A method of producing an ingestible pharmaceutical composition, comprising:
- receiving, with a controller, instructions regarding a first tablet dosage and a second tablet dosage;
- dispensing a first amount of a solid active pharmaceutical ingredient from a first dispenser;
- dispensing a first amount of an excipient from a second dispenser;
- blending the first amount of the solid active pharmaceutical ingredient and the first amount of the excipient in a blender to form a first mixture;
- forming a first tablet from the first mixture;
- dispensing a second amount of the solid active pharmaceutical ingredient from the first dispenser;
- dispensing a second amount of the excipient from the second dispenser;
- blending the second amount of the solid active pharmaceutical ingredient and the second amount of the excipient in the blender to form a second mixture;
- and
- forming a second tablet from the second mixture,
- wherein the first dispenser, the second dispenser and the blender are coupled to a frame, and
- wherein the first amount of the solid active pharmaceutical ingredient and the first amount of the excipient are dispensed into a carriage.
A method of producing an ingestible pharmaceutical composition, comprising:
- receiving, with a controller, instructions regarding a first drug type and a second drug type;
- dispensing a first solid active pharmaceutical ingredient;
- dispensing a first excipient;
- blending the first solid active pharmaceutical ingredient and the first excipient to form a first mixture having a volume of less than 10 L;
- forming a tablet from the first mixture;
- dispensing a second solid active pharmaceutical ingredient, the second solid active pharmaceutical ingredient being compositionally different from the first solid active pharmaceutical ingredient;
- dispensing a second excipient;
- blending the second solid active pharmaceutical ingredient and the second excipient to form a second mixture;
- and
- forming a tablet from the second mixture,
- wherein the first solid active pharmaceutical ingredient and the first excipient are dispensed into a carriage.
A system for producing an ingestible pharmaceutical composition, comprising:
- a plurality of dispensers;
- a first weigh scale configured to weigh material dispensed from the plurality of dispensers;
- and
- a blender configured to receive and mix the material dispensed from the plurality of dispensers to form a first mixture, the blender having a mixing vessel having a volume of less than 10 L;
- and
- a carriage configured to convey the material dispensed from the plurality of dispensers to the blender.
Dependencies are inferred from the claim text.