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US 10,702,469 B2Granted
Non-aqueous topical solution of diclofenac and process for preparing the same
AssigneeTroikaa Pharmaceuticals Limited
InventorKetan R. Patel
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Abstract
A non-aqueous topical solution composition of pharmaceutically acceptable salt of diclofenac is disclosed. The non-aqueous topical solution composition comprises therapeutically effective amount of pharmaceutically acceptable salt of diclofenac, solublizer, penetration enhancer and solvent, and optionally a humectant, counter irritant, additional penetration enhancer and anti-oxidants and a process for preparing the same.
Claims3
A novel composition comprising:
- an effective amount of pharmaceutically acceptable salt of diclofenac in the range of 1.16% to 5% w/v;
- a penetration enhancer and solubilizer in the range of 10 to 20% v/v of a lower chain alcohol;
- a solvent in an amount greater than 75% and selected from propylene glycol, glycofurol and mixtures thereof;
- and
- an additional penetration enhancer in the range of 1 to 5% w/v, and selected from the group consisting of
- oleic acid,
- N-methyl-pyrrolidone (NMP),
- 2-methyl-pyrrolidone, and
- 1-methyl-pyrrolidone;
- wherein the composition is a non-aqueous topical solution.
7 more elements
Dependencies are inferred from the claim text.