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US 10,702,245 B2Granted
Method of detecting microbubbles in a vessel
AssigneeNational Tsing Hua University
InventorsHsu-Hsia Peng, Che-Wei Wu
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Abstract
The present invention provides a method of detecting microbubbles in a vessel of an affected part, comprising aggregates the microbubbles, acquiring phase-contrast magnetic resonance images and analyzing the phase-contrast magnetic resonance images. Thus, we can detect or monitor the size and location of the microbubbles in vessels of any part of body.
Claims12
A method of detecting microbubbles in a vessel of an affected part, comprising:
- delivering an ultrasonic energy within the affected part to aggregate the microbubbles to form a plurality of aggregated microbubbles;
- acquiring a phase-contrast magnetic resonance image by a magnetic resonance device;
- and
- locating the plurality of aggregated microbubbles by analyzing the phase-contrast magnetic resonance image to obtain a velocity value and a vorticity value of fluid flow in a region of interest in the phase-contrast magnetic resonance image;
- wherein the plurality of aggregated microbubbles is located at wherein the velocity value is within the lowest 10%, and the vorticity value is −0.18 to 0.18;
- wherein the ultrasonic energy has a frequency of 0.83-1.25 MHz and an acoustic pressure of 0.025-0.1 MPa;
- and
- wherein the region of interest is an area of the vessel.
5 more elements
Dependencies are inferred from the claim text.