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US 10,702,218 B2Granted
Procedure for the acquisition of data for the detection of angiogenesis in lower limbs
AssigneesServicio Andaluz De Salud, Universidad de Córdoba
InventorsJosé García-revillo García, Miguel Canis López, Noelia Romero Mata
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Abstract
The invention relates to a method for obtaining useful data about the angiogenesis in a patient's lower limbs, and particularly in the lower limbs of patients with diabetes subjected to treatment.
Claims10
A method for assessing the presence of angiogenesis in a patient's lower limbs after injecting a contrast agent in the patient, characterized in that it comprises the following steps:
- taking at least one time series of successive transverse slices in at least one position of the patient's limb by means of a CT scanner;
- obtaining a perfusion CT image corresponding to said at least one time series of successive transverse slices;
- selecting an analysis region in said at least one perfusion CT image;
- calculating the perfusion parameters BF, BV, PS, and TTM corresponding to the analysis region selected in the preceding perfusion CT image;
- comparing said calculated perfusion parameters with previously obtained perfusion parameters in order to determine if angiogenesis is taking place, wherein there is presence of angiogenesis if an improvement of at least two of the parameter BF, BV, PS, and TTM is observed, improvement being defined as in increase of at least 5% for parameters BF, BV, and PS and a decrease of at least 5% for parameter TTM;
- and
- wherein taking the time series of transverse slices starts between 13 seconds and 15 second after injecting the contrast agent.
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