Method for alcoholysis of amide
AssigneeAsymchem Laboratories (Tianjin) Co., Ltd.
InventorsJiangping Lu, Qinglan Pei, Jinquan Yu, Enxuan Zhang
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Abstract
Provided is a method for the alcoholysis of an amide. The method comprises subjecting an amide-containing compound to alcoholysis under alkaline conditions using an epoxy compound as an accelerant of alcoholysis, the method comprising: mixing the amide-containing compound, the epoxy compound, a pH adjuster and a solvent to form an alkaline reaction system, the pH of the alkaline reaction system being 7.5-9.5; reacting the alkaline reaction system at 50° C. ˜150° C. to subject the amide-containing compound to alcoholysis.
Claims12
A method for alcoholysis of an amide, the method comprising:
- mixing the amide-containing compound, the epoxy compound, a pH adjuster and a solvent to form an alkaline reaction system, the pH of the alkaline reaction system being 7.5-9.5;
- reacting the alkaline reaction system at 50° C.-150° C. to subject the amide-containing compound to alcoholysis,
- calculated in the molar ratio of the epoxy compound to an amide group, the ratio of the epoxy compound used to the amide-containing compound used is 1-5:1, the amide-containing compound has a formula I, the formula I is
- wherein the R1, and the R2 are each independently selected from any one of an alkyl group, an aryl group, a substituted alkyl group and a substituted aryl group;
- the epoxy compound has a formula II, the formula II is
- wherein the R3 and the R4 are each independently selected from any one of H, an alkyl group and an aryl group,
- the solvent is selected from any one or more of a group of methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isoamyl alcohol, ethylene glycol and glycerol.
Dependencies are inferred from the claim text.