Chemical reaction vessel and synthesis systems and methods
OwnerAlexander S. Waddell, David W. Ribblett +1inventors
InventorsAlexander S. Waddell, David W. Ribblett, James Cain
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Abstract
Apparatus and methods utilizing induction-heat energy for heating reactions associated with chemical synthesis, such as peptide synthesis reactions involving activation, deprotection, coupling, and cleavage. Thorough agitation of the contents of reaction vessels during heating, real-time monitoring and adjustment of temperature and/or reaction duration, independent control of different reaction vessels, and scalability are also described.
Claims20
A chemical synthesis reaction-heating platform, comprising:
- one or more reaction vessels, and
- a source of induction-heat energy configured to heat a content of said one or more reaction vessels,
- wherein said one or more reaction vessels is coated with a heat-conductive material that comprises a plurality of layers of a metal conductor paste, and
- wherein said platform is configured to shake or mix said content in the one or more reaction vessels during a process of heating said content.
An instrument for solid phase peptide synthesis, comprising:
- one or more reaction vessels, and
- a source of induction-heat energy configured to heat a content of said one or more reaction vessels,
- and
- means for actuating and controlling fluid transfers and heating necessary for peptide synthesis;
- wherein said one or more reaction vessels is coated with a heat-conductive material that contains a plurality of layer of a metal conductor paste, and
- wherein said instrument is configured to shake or mix said content of the one or more reaction vessels during a process of heating of said content.
An instrument for solid phase peptide synthesis, comprising:
- one or more reaction vessels, and
- a source of induction-heat energy configured to heat contents of said one or more reaction vessels,
- wherein said one or more reaction vessels is coated with a heat-conductive material,
- means for actuating and controlling fluid transfers and heating necessary for peptide synthesis,
- and
- an infrared (IR) heat temperature sensor,
- wherein said one or more reaction vessels is configured to diffuse and homogenize IR radiation,
- and
- wherein said instrument is configured to shake or mix said contents of the one or more reaction vessels during a process of heating of said contents.
Dependencies are inferred from the claim text.