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AssigneesThe Johns Hopkins University, Rutgers, The State University of New Jersey
InventorsGyanu Lamichhane, Craig A. Townsend, Evan Lloyd, Amit Kaushik, Pankaj Kumar, Joel Freundlich, Shaogang Li, Sean Ekins, Nicole Parrish
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New antimicrobials targeting L,D-transpeptidases, non-classical cysteine peptidases, have been developed and their unique chemical structures identified. Carbapenems and penems of the present invention are unique among β-lactams as they acylate and inhibit L,D-transpeptidases, which likely results in their superior antimicrobial potency. These new antimicrobial agents can be used alone, or in combination with other classic antimicrobial agents that target D,D transpeptidases, when treating bacterial infections.
A compound of Formula (I):
A method of inhibiting L,D-transpeptidase activity in a subject with a bacterial infection, comprising administering to the subject comprising a bacteria with L,D-transpeptidase, an effective amount of a compound, salt, solvate, or stereoisomer of any one of the compounds selected from the group consisting of:
Dependencies are inferred from the claim text.