Methods and compositions for modulating TH-GM cell function
AssigneeNational University of Singapore
InventorsFu Xin-Yuan, Wanqiang Sheng, Yongliang Zhang, Fan Yang
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Abstract
Disclosed herein is a T-helper cell (“TH-GM” cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating TH-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying TH-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from and/or in addition to non-TH-GM-mediated (e.g., TNF-α-mediated) inflammatory disorders, are also provided.
Claims11
A method of treating an inflammatory disorder in a patient, comprising administering an effective amount of a modulating agent that inhibits Th-GM function,
- wherein the patient exhibits a limited response or no response to a TNF-α inhibitor therapy, wherein the inflammatory disorder is mediated by granulocyte macrophage colony-stimulating factor (GM-CSF)-secreting T-helper (Th-GM) cells
- wherein the modulating agent is a signal transducer and activator of transcription 5 (STAT5) inhibitor, and
- wherein the inflammatory disorder is rheumatoid arthritis.
A method of treating an inflammatory disorder in a patient, comprising administering an effective amount of a modulating agent that inhibits Th-GM function,
- wherein the patient exhibits a limited response or no response to a TNF-α inhibitor therapy,
- wherein the modulating agent is pimozide, and
- wherein the inflammatory disorder is rheumatoid arthritis.
Dependencies are inferred from the claim text.