# US 10,690,659 B2 · Measuring physical and biochemical parameters with mobile devices > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,690,659 B2 - Document ID: US10690659B2 - Status: Granted - Kind: B2 - Application number: 15/489,747 - Filed: 2017-04-18 - Published: 2017-08-03 - Granted: 2020-06-23 - Earliest claimed: 2014-02-17 - Assignees: Ixensor Co., Ltd. - Applicants: Ixensor Co., Ltd. - Inventors: Yenyu Chen; Tungmeng Tsai; Chieh Hsiao Chen; Hungchih Wang; Yuwei Tang; Chiachun Hung; Chihchieh Wu - Web page: https://patentgrep.com/patent/US10690659B2 ## CPC - G01N 33/525: {Multi-layer analytical elements} - G01N 21/8483: {Investigating reagent band (test-element handling not specific to a test method G01N33/4875; analytical elements specific to chemical analysis of biological material G01N33/52; autometer with reagent band G01N35/04)} - G01N 33/4875: {Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method (test-elements per se B01L, automatic analysers G01N35/00, in-vivo analysis on the human body for medical diagnosis A61B)} - H04B 1/3888: Arrangements for carrying or protecting transceivers - H04M 1/185: {Improving the shock resistance of the housing, e.g. by increasing the rigidity} - G06T 7/90: Determination of colour characteristics - H04M 1/0254: {comprising one or a plurality of mechanically detachable modules} - H04M 1/0264: {for a camera module assembly} - H04M 1/21: Combinations with auxiliary equipment, e.g. with clocks or memoranda pads - H04M 2250/52: including functional features of a camera - H04N 17/02: for colour television signals - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - H04B: TRANSMISSION - H04M: TELEPHONIC COMMUNICATION (circuits for controlling other apparatus via a telephone cable and not involving telephone switching apparatus G08) - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - H04N: PICTORIAL COMMUNICATION, e.g. TELEVISION ## Abstract A method for a mobile computing device with a camera and a screen to measure a test strip in a test strip module includes, in a calibration phase before a sample is introduced to a reaction area on the test strip, detecting with the camera an ambient light effect when the test strip module is mounted on the face of the mobile computing device. In a measurement phase after the sample is introduced to the reaction area on the test strip, the method also includes illuminating the test strip with a light provided by a light source area on the screen, detecting with the camera one or more colors of the reaction area, correcting the detected one or more colors for the ambient light effect, correlating the corrected one or more colors to an analyte property, and displaying a value of the analyte property on the screen. ## Claims ### Claim 1 A method for a mobile computing device to measure a test strip in a test strip module, the method comprising: in a calibration phase before a sample is introduced to a reaction area on the test strip, detecting with a camera on a face of the mobile computing device an ambient light effect from an ambient light leaking into the test strip module through an interface between a case of the test strip module and the face of the mobile computing device when the test strip module is mounted on the face of the mobile computing device, wherein detecting the ambient light effect comprises: capturing a series of images under incrementing light intensities; linearizing a response of the camera based on the series; and determining a formula for a corrected color based a first image in the series that is captured with the light source area off and a second in the series that is captured with the light source area on, comprising: C corrected = ( C detected - C on ) ⁢ C actual C on - C off , or C corrected = ( C detected - C off ) ⁢ ⁢ c actual C on - C off , where Coff is a detected color of a color calibration area in the first image, Con is a detected color of the color calibration area in the second image, Cactual is an actual color of the color calibration area, Cdetected is a detected color in a third image captured with the light source area on in the measurement phase, and Ccorrected is the corrected color value; in a measurement phase after the sample is introduced to the reaction area on the test strip: illuminating the test strip with a light emitted by a light source area of a screen on the face of the mobile computing device, wherein the light source area corresponds to a portion of the screen; detecting with the camera one or more colors of the reaction area; correcting the detected one or more colors for the ambient light effect; correlating the corrected one or more colors to an analyte property; and displaying a value of the analyte property on the screen. ### Claim 2 (depends on 1) The method of claim 1, wherein correcting the detected one or more colors for the ambient light effect includes subtracting the ambient light effect from the detected color. ### Claim 3 (depends on 1) The method of claim 1, wherein correlating the corrected one or more colors to an analyte property comprises: determining a slope of a line between first and second points, the first point comprising a first detected color of a desired area and a first time at which the first detected color was captured in a first image during the measurement phase, the second point comprising a second detected color and a second time at which the second detected color was captured in a second image during the measurement phase; and correlating the slope to the value of the analyte property based on a chart. ### Claim 4 (depends on 1) The method of claim 1, wherein correlating the corrected one or more colors to an analyte property comprises: determining an ambient light level; determining a detected color of a desired area captured in an image during the measurement phase; using a known color or known colors of a color calibration area on the image to determine a rescaled color from the detected color; and correlating the ambient light level and the rescaled color to the value of the analyte property based on a chart. ### Claim 5 (depends on 1) The method of claim 1, further comprising performing a pre-test by: determining if an airplane mode of the mobile computing device is turned on, wherein the method proceeds to the calibration and the measurement phases when the airplane mode is turned on; determining if a battery capacity is greater than a first threshold, wherein the method proceeds to the calibration and the measurement phases when the battery capacity is greater than the first threshold; determining if the mobile computing device is running on an internal battery, wherein the method proceeds to the calibration and the measurement phases when the mobile computing device is running on the internal battery; or determining if an ambient light level is less than a second threshold, wherein the method proceeds to the calibration and the measurement phases when the ambient light level is less than the second threshold. ### Claim 6 (depends on 1) The method of claim 1, further comprising, prior to the calibration phase: determining if the test strip is correctly positioned, wherein the method proceeds to the calibration and the measurement phases when the test strip is correctly positioned. ### Claim 7 (depends on 6) The method of claim 6, wherein determining if the test strip is correctly positioned comprises identifying the test strip in an image based on a shape, a color, or a light intensity. ### Claim 8 (depends on 7) The method of claim 7, wherein determining if the test strip is correctly positioned comprises further comprises taking a cross-section of a reaction area on the test strip in the image and determining if sections of the cross-section have colors that correspond to actual colors of the reaction area. ### Claim 9 (depends on 1) The method of claim 1, further comprising, in the calibration phase: determining if the ambient light effect is greater than a threshold; and when the ambient light effect is greater than the threshold, displaying on the screen a suggestion to move the mobile computing device or shield the test strip module. ### Claim 10 (depends on 9) The method of claim 9, wherein the suggestion comprises shielding the test strip module with a hand or a box top that is part of a packaging of the test strip module. ### Claim 11 (depends on 1) The method of claim 1, further comprising, before operating in the calibration phase and the measurement phase, limiting any notification to a location away from the light source area of the screen. ### Claim 12 (depends on 11) The method of claim 11, wherein limiting any notification comprises locking an orientation of the mobile computing device so notifications appear along one edge of the screen instead of another edge that includes the light source area of the screen. ### Claim 13 (depends on 1) The method of claim 1, further comprising, locking a white balance for the camera by taking an image with low light immediately before taking a second image with a light emitted by the light source area of the screen. ### Claim 14 (depends on 1) The method of claim 1, further comprising, in the measurement phase, causing the mobile computing device to vibrate.