Bioconversion process for producing nylon-7, nylon-7,7 and polyesters
AssigneeInvista North America S.A.R.L.
InventorsPaul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie, Benjamin D. Herzog
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Abstract
Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
Claims8
A method of converting a compound, the method comprising contacting pimeloyl-CoA (PCoA) or pimeloyl acyl carrier protein (PACP) with a single enzyme that catalyzes the reduction of PCoA or PACP to pimelic acid semialdehyde (PAS) in a single reaction, wherein PAS is produced, and wherein the single enzyme that catalyzes the reduction of PCoA or PACP to PAS in a single reaction is a fatty-acyl-CoA reductase in EC 1.2.1.3, EC 1.2.1.10, EC 1.2.1.22, EC 1.2.1.50, or EC 1.2.1.76, a fatty-acyl-[acp]-reductase in EC 1.2.1.80, or an aldehyde dehydrogenase in EC 1.2.1.10, EC 1.2.1.76, or EC 1.2.1.50.
Dependencies are inferred from the claim text.