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US 10,689,462 B2Granted
Therapeutic and imaging compositions and uses thereof
AssigneePurdue Research Foundation
InventorsDavid H. Thompson, Aditya Kulkarni, Christopher Collins, Yawo Mondjinou
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Abstract
Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes various embodiments of the present invention.
Claims8
A polyrotaxane comprising the general formula:
- or a salt thereof,
- wherein:
- n is an integer from 1 to 30;
- C and C′ are the same or different and represent endcapping groups of the formula:
- wherein:
- L1 is a (C1-C6)hydrocarbylene group,
- G1 and G2, together, form a radical having the formula:
- wherein each L2 is independently a bond or acyl;
- each G3 is a substituted or unsubstituted (C6-C50)hydrocarbyl group, interrupted by 0 to 5 groups chosen from —O—, —NH—, and —S—;
- and
- each s is independently an integer from 1 to 5;
- and
- t is an integer from 2 to 5:
- B is a poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) (PEG-PPG-PEG) triblock copolymer;
- and
- A is a beta cyclodextrin;
- wherein G3 is not a substituted or unsubstituted (C6-C12)aryl group.
14 more elements
Dependencies are inferred from the claim text.