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US 10,689,445 B2Granted
Anti-PD-L1 antibodies and diagnostic uses thereof
AssigneesVentana Medical Systems, Inc., Spring BioScience Corporation
InventorsMarcin Kowanetz, Hartmut Koeppen, Zachary Boyd, Zhiming Liao, Yifei Zhu, Bharathi Vennapusa, Patrick C. Roche
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Abstract
The invention provides programmed death-ligand 1 (PD-L1) antibodies and methods of using the same.
Claims28
An isolated antibody that specifically binds PD-L1, wherein the antibody comprises a heavy chain variable domain (VH) and a light chain variable domain (VL) that comprises the following hypervariable regions (HVRs):
- (a) an HVR-H1 comprising the amino acid sequence of SNGLT (SEQ ID NO:
- 2);
- (b) an HVR-H2 comprising the amino acid sequence of TINKDASAYYASWAKG (SEQ ID NO:
- 3);
- (c) an HVR-H3 comprising the amino acid sequence of IAFKTGTSI (SEQ ID NO:4);
- (d) an HVR-L1 comprising the amino acid sequence of QASESVYSNNYLS (SEQ ID NO:
- 9);
- (e) an HVR-L2 comprising the amino acid sequence of LASTLAS (SEQ ID NO:
- 10);
- and
- (f) an HVR-L3 comprising the amino acid sequence of IGGKSSSTDGNA (SEQ ID NO:
- 11).
9 more elements
Dependencies are inferred from the claim text.