Hydrogen sulfide precursors and conjugates thereof

A compound according to Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• subscripts a and b are each 1;
• each subscript c is 0;
• L1 and L2 are each a bond;
• R1 and R2 are taken together to form C6-C10 aryl, which is optionally substituted with 1-3 R4;
• each R4 is independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 aminoalkyl, C1-C6 aminoalkoxy, C3-C6 cycloalkyl;
• R3 is O;
• W is O;
• Y is a bond and R10 is H, or
• Y is —S— and R10 is selected from the group consisting of C1-C6 alkyl and (C6-C10 aryl)-(C1-C6 alkyl), wherein C1-C6 alkyl and (C6-C10 aryl)-(C1-C6 alkyl) are optionally substituted with 1-5 R10a, or wherein C1-C6 alkyl and (C6-C10 aryl)-(C1-C6 alkyl) optionally substituted with —OR′ wherein R′ is C1-6 alkyl;
• Z is selected from the group consisting of —C(═O)R6, —C(═O)OR6, —(CH2)xOR6, —(CH2)x(C(═O)OR6, —(CH2)xOC(═O)R6, —(CH2)xOP(═O)(OR6)x, —OP(═O)(OR6)x, —P(═O)(OR6)x, and R7, wherein each subscript x is independently 0, 1, 2, 3, or 4;
• each R8 is independently selected from the group consisting of H and C1-C6 alkyl,
• each R9 is independently C1-C6 alkyl,
• wherein one R8 is optionally taken together with one R9 to form a double bond;
• each R10a is independently selected from the group consisting of C1-C6 alkyl, —C(═O)OR5, —NR5C(═O)OR5, and a moiety —W—Z;
• each R5 is independently selected from the group consisting of H and C1-C4 alkyl;
• each R6 is independently selected from the group consisting of C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, and C3-C4 cycloalkyl;
• and
• R7 is a monosaccharide or a non-steroidal anti-inflammatory drug, wherein the non-steroidal anti-inflammatory drug is selected from the group consisting of ibuprofen, naproxen, sulindac, aceclofenac, salicylates, indomethacin, flurbiprofen, diclofenac, ketorolac, etodolac, fenoprofen, flufenamic acid, ketoprofen, mefenamic acid, diflunisal, tolmetin, ketorolac, aspirin, and lumiracoxib.