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AssigneeHyperstem SA
InventorsAngelo Luigi Vescovi, Elena Binda
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The described invention relates to a pharmaceutical composition comprising a therapeutically effect amount of a therapeutic agent, wherein the therapeutic agent is effective (1) to reduce tumor growth, migration, invasion or a combination and (2) improve subject survival relative to a control. The described invention also relates to a method of treating a subject with a tumor, the method comprising: (1) providing a pharmaceutical composition; and (2) administering the pharmaceutical composition, wherein the composition comprises a therapeutically effective amount of a therapeutic agent which is effective to reduce tumor growth, migration, invasion or a combination. The method may further comprise preparing therapeutic agent and preparing the pharmaceutical composition. The therapeutic agents include but are not limited to Wnt5a derivative peptides or Wnt5a antagonists or Wnt5a blocking antibody. The tumor comprises a population of cancer stem cells.
A pharmaceutical composition comprising a therapeutic amount of a therapeutic agent and a pharmaceutically acceptable carrier, wherein the therapeutic agent is a t-butyloxycarbonyl peptide derivative of Wnt5a, selected from Peptide A (SEQ ID NO:
A method for treating a solid brain tumor comprising a population of tumor-propagating cells (TPCs) with stem-like characteristics in a subject, said method comprising administering to the subject a pharmaceutical composition comprising a therapeutic amount of a therapeutic agent and a pharmaceutically acceptable carrier, wherein the therapeutic agent is a t-butyloxycarbonyl peptide derivative of Wnt5a, selected from Peptide A (SEQ ID NO:
A t-butyloxycarbonyl peptide derivative of Wnt5a, selected from Peptide A (SEQ ID NO:
Dependencies are inferred from the claim text.