Nanoparticles and their use in cancer therapy
AssigneeMidatech Limited
InventorsJon Golding, Phillip Williams, Meike Roskamp
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Abstract
The present invention provides a nanoparticle comprising a core comprising a metal; and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group, for use in a method of treating a cancer, particularly skin cancer, in a mammalian subject. Also disclosed are methods of treatment by administering the nanoparticles alone or in combination with radiotherapy.
Claims13
A method of treatment of a squamous cell carcinoma in a mammalian subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a nanoparticle comprising a core comprising gold;
- and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising amine-functionalized oligo (ethylene glycol) and at least a second species of ligand comprising a monosaccharide selected from the group:
- galactose, glucose and N-acetylglucosamine said nanoparticle killing one or more cancer cells in
- i) the absence of any cytotoxic drug or toxin bound to the nanoparticle core or corona and
- ii) in the absence of applied radiation.
Dependencies are inferred from the claim text.