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AssigneeCorbion Biotech, Inc.
InventorsScott Franklin, Aravind Somanchi, George Rudenko, Riyaz Bhat, Xinhua Zhao, Risha Bond, Walter Rakitsky, Alejandro Marangoni, Diza Braksmayer
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Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
A microbial oil comprising triglycerides, wherein the microbial oil has an altered fatty acid profile relative to a microbial oil produced by a non-recombinant oleaginous microbe, the microbial oil comprising at least 45% of triglycerides being a combination of palmitic-oleic-palmitic triglyceride, stearic-oleic-stearic triglyceride, and palmitic-oleic-stearic triglyceride, and wherein the oleaginous microbe comprises an exogenous gene encoding ketoacyl-ACP synthase (KAS).
Dependencies are inferred from the claim text.