Polymers, hydrogels, and uses thereof

A polymer of Formula (I):

• or a salt thereof, wherein:
• XA is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORXA, —N(RXA)2, —C(═NRXA)RXA, —C(═NRXA)ORXA, —C(═NRXA)N(RXA)2, —C(═O)RXA, —C(═O)ORXA, or —C(═O)N(RXA)2, wherein each instance of RXA is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of RXA are joined to form a substituted or unsubstituted heterocyclic or substituted or unsubstituted heteroaryl ring;
• t is 10 to 2000;
• and
• each instance of R is independently a side chain selected from:
• boronic acid-containing moieties of Formula (a):
• wherein:
• each instance of RAA is independently halogen, substituted or unsubstituted alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORa, —N(Ra)2, —SRa, —CN, —SCN, —C(═NRa)Ra, —C(═NRa)ORa, —C(═NRa)N(Ra)2, —C(═O)Ra, —C(═O)ORa, —C(═O)N(Ra)2, —NO2, —NRaC(═O)Ra, —NRaC(═O)ORa, —NRaC(═O)N(Ra)2, —OC(═O)Ra, —OC(═O)ORa, or —OC(═O)N(Ra)2;
• each instance of Ra is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of Ra are joined to form a substituted or unsubstituted, heterocyclic ring, or substituted or unsubstituted, heteroaryl ring;
• k is 0, 1, 2, 3, or 4;
• LA is a substituted or unsubstituted, C1-6 alkylene chain, optionally wherein one or more chain atoms of the alkylene chain are independently replaced with —O—, —NRLA—, or —C(═O)—, wherein each instance of RLA is independently hydrogen, substituted or unsubstituted, C1-6 alkyl, or a nitrogen protecting group;
• and
• polyol-containing moieties of Formula (c):
• wherein:
• X is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —C(═O)Ra, —C(═O)ORa, or —C(═O)N(Ra)2;
• m is an integer between 1 and 10, inclusive;
• LC is a substituted or unsubstituted, C1-10 alkylene chain, optionally wherein one or more chain atoms of the alkylene chain are independently replaced with —O—, —NRLB—, or —C(═O)—, wherein each instance of RLB is independently hydrogen, substituted or unsubstituted, C1-6 alkyl, or a nitrogen protecting group;
• and
• amine-containing moieties of Formula (b):
• wherein:
• RN is independently hydrogen or substituted or unsubstituted C1-6 alkyl;
• RNPG is a nitrogen protecting group;
• and
• LB is a substituted or unsubstituted, C1-6 alkylene chain, optionally wherein one or more chain atoms of the alkylene chain are independently replaced with —O—, —NRLB—, or —C(═O)—, wherein each instance of RLB is independently hydrogen, substituted or unsubstituted C1-6 alkyl, or a nitrogen protecting group;
• and
• aliphatic moieties of Formula (d):
• wherein:
• LD is a substituted or unsubstituted, C1-6 alkylene chain, optionally wherein one or more chain atoms of the alkylene chain are independently replaced with —O—, —NRLD—, or —C(═O)—, wherein RLD is independently hydrogen, substituted or unsubstituted C1-6 alkyl, or a nitrogen protecting group;
• and
• RD1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORD2, or —NRD22, wherein RD2 is hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted alkenyl, optionally wherein one or more chain atoms of an alkyl chain are independently replaced with alkenyl, —O—, —NRLD—, or —C(═O)—;
• provided that the polymer contains at least one boronic acid-containing moiety of Formula (a) and at least on polyol-containing moiety of Formula (c).