Methods for treating cancer using GRM8 inhibitors
AssigneeFlagship Pioneering Innovations V, Inc.
InventorsAvak Kahvejian, Jordi Mata-Fink, Jonathan Barry Hurov, Chengyi Jenny Shu, George Huck Neubauer, Julian Alexander Stanley
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Abstract
The present invention provides methods for treating cancer using mGluR8 inhibitors, such as mGluR8 inhibitory antibodies and small molecules. The invention also features compositions containing mGluR8 inhibitors, methods of diagnosing patients with mGluR8-associated cancer, and methods of predicting the response of cancer in a subject to treatment with mGluR8 inhibitors.
Claims1
A method of treating a human subject identified as having a macrophage infiltrated tumor, the method comprising administering to the subject an amount of a small molecule mGluR8 antagonist effective to increase IL-8 production by macrophages, thereby treating the subject.
Dependencies are inferred from the claim text.