Compounds as DNA probes, methods and applications thereof
AssigneeJawaharlal Nehru Centre for Advanced Scientific Research
InventorsGovindaraju Thimmaiah, Nagarjun Narayanaswamy
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Abstract
The present disclosure relates to the field of pharmaceutical chemistry and biotechnology. The present disclosure also relates to a compound of Formula I and a process of preparation thereof. The disclosure furthermore relates to methods/use of Formula I compounds as DNA probes. Said Formula I compounds are employed for recognizing specific DNA sequences by near Infra-red (NIR)-Fluorescence Switch-on mechanism, and have related applications including but not limited to cell imaging. Also, method of treating parasitic infections by employing the present compound of Formula I is provided.
Claims14
A compound of Formula I:
- wherein:
- X is selected from the group consisting of oxygen, sulphur, and selenium;
- R1, R2, R3, R4, R5, R6, R7, and R8 are hydrogen;
- ‘R9’ is selected from the group consisting of H and —(CH2)n—, wherein ‘n’ is 1-6;
- ‘R10’ is selected from the group consisting of hydrogen, —OH, methyl, amine, terminal alkyne, alkene, alkyl acid, amine acid, and sulfonates (SO3−).
The compound of Formula I selected from a group consisting of:
Dependencies are inferred from the claim text.